TABLE 5.

Cox proportional hazard model of predictors of HCC comparing all subjects with HBV (with and without concomitant liver disease) not on NAs who did not meet the 2018 AASLD HBV treatment guidelines and developed HCC to subjects with HBV not on NAs who did not meet the 2018 AASLD HBV treatment guidelines and did not develop HCC

Factor	HBV/no NA/HCC (n = 133) n (%) or median (IQR)	HBV/no NA/no HCC (n = 1110) n (%) or median (IQR)	HR (95% CI)	p‐Value
Cirrhosis	115 of 133 (86.5%)	111 (10%)	10 (5.8–17.5)	<0.001
NAs (mmol/L)	137.5 (136–139)	139 (138–140)	0.96 (0.91–1.02)	0.18
ALT > 47 IU/L	67 (48.2–107)	33 (26–41)	1.004 (1.002–1.006)	<0.001
Age > 54 years	61 (55.2–69.5)	42 (33–53)	1.04 (1.03–1.06)	<0.001
Albumin > 4 g/dl	3.3 (2.8–3.7)	4.2 (3.9–4.4)	0.4 (0.3–0.6)	<0.001
ALD	48 (36%)	10 (1%)	1.9 (1.2–3.1)	0.007
NAFLD	16 (15%)	62 (5%)	1.7 (1.1–2.8)	0.02
HCV	34 (22%)	92 (8%)	1.6 (0.9–2.7)	0.09

Abbreviation: HR, hazard ratio.