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. 2022 Oct 11;12:1028899. doi: 10.3389/fcimb.2022.1028899

Figure 3.

Figure 3

Pre-exposure to S. japonicum eggs downregulated Th17 immune response in the TNBS-induced experimental colitis. The proportion of IL-17+ Th17 in spleen CD4+ T cells (A, B). The mRNA expression level of Th17 specific transcription factor RORγt in spleen (C). The concentration of IL-17A in serum (D) and in splenic supernatant (E). Data are expressed as means ± SEMs based on 6 mice in each group and from 2 independent experiments. Asterisks mark significant differences among different groups (*P < 0.05, ***P < 0.001).