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. 2022 Oct 11;13:990148. doi: 10.3389/fendo.2022.990148

Table 4.

Description of clinical data at diagnosis of hypoaldosteronism cases without hyperkalemia.

Sex/Age y Comorbidities Concomitant treatment SK1 SNa1 SC2 GFR3 HCO31 SK/UK ratio FEK UK/UC ratio UNa1 UK1 UNa/uK ratio Uosm4 TTKG Cortisol5 PAC6
Case 1 F/68 HTA, PDH ACEI/ARB 4.2 130 0.77 150 NM 0.14 9.5 51.9 81 31 2.61 490 4.2 14.8 88
Case 2 F/83 HTA, PDH, MN Hep, ACEI/ARB, TD 3.6 118 0.46 186 NM 0.11 NM NM 60 32 1.88 527 4.4 29 7
Case 3 F/89 DM, HTA, LSI ACEI/ARB, LD 4.4 134 1.17 103 NM 0.23 11.2 42.1 60 19 3.16 285 4.3 15.9 NM
Case 4 M/78 HTA, PDH, LSI ACEI/ARB 4.6 126 1.36 86 NM 0.18 NM NM 68 25 2.72 294 5 16.3 218
Case 5 F/90 DM, HTA, MN, LSI CG, βB, ACEI/ARB, LD 4.2 124 0.97 129 NM 0.10 NM NM 36 41 0.88 514 5.3 NM NM
Case 6 F/90 HTA, CKD, RT, MN, LSI ACEI/ARB 4.3 127 1.17 75 22.3 0.19 4.8 17.6 36 23 1.57 312 4.6 21 83

F, female; M, male; HTA, hypertension; DM, diabetes mellitus; CKD, chronic kidney disease; RT, renal transplantation; PDH, prior dilutional hyponatremia; MN, malnutrition; low-salt intake; ACEI/ARB, angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers; Hep, heparin; TD, thiazide; LD, loop diuretics; CG, chronic glucocorticoid therapy ≥ 6 weeks; βB, beta-blockers; NM, no measured. SK, serum potassium mmol/L; SNa, serum sodium; SC, serum creatinine; GFR, glomerular filtrate rate; HCO3, blood bicarbonate; FEK, fractional excretion of K; UK, urine potassium; UC, urine creatinine; UNa, urinary sodium; Uosm, urine osmolality; TTKG, transtubular potassium gradient.

1mmol/L, 2mg/dL, 3ml/min/1.73m2, 4mOsm/kg, 5µg/dL, 6pg/mL.