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. 2022 Oct 11;12:931035. doi: 10.3389/fonc.2022.931035

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Copyright © 2022 Elie, Giffard, Blanc-Fournier, Morice, Brachet, Dutoit, Plancoulaine and Poulain

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Distribution of values of principal component 1 for P-ERK and three Gaussian functions. Automatic thresholds are determined with the algorithm of the Gaussian Mixture Model. (B) The threshold values correspond to crossing between Gaussians. (C) The highest threshold was selected and used as the 0-value. (D) Histogram representation of P-ERK marker score per patient by rapid reading. White bars corresponding to discordance between experts and IP. (E) Histogram representation of Bim marker score per patient. (F) Histogram representation of P-Mcl-1 marker score per patient.