TABLE 1.
Patient characteristics.
| Variable | Total (n = 975) | Tigecycline (n = 485) | Imipenem–cilastatin (n = 490) | p value |
|---|---|---|---|---|
| Age (years) | 61.0 (42.0–71.0) | 62.0 (45.0–73.0) | 60.0 (38.0–70.0) | 0.001 |
| Sex, female (%) | 312 (32.0%) | 139 (28.7%) | 173 (35.3%) | 0.026 |
| ICU admission (%) | 448 (45.9%) | 219 (45.2%) | 229 (46.7%) | 0.621 |
| Comorbidities (%) | ||||
| Diabetes mellitus | 158 (16.2%) | 91 (18.8%) | 67 (13.7%) | 0.031 |
| Hypertension | 285 (29.2%) | 170 (35.1%) | 115 (23.5%) | <0.001 |
| Chronic heart failure | 63 (6.5%) | 46 (9.5%) | 17 (3.5%) | <0.001 |
| Atrial fibrillation | 47 (4.8%) | 42 (8.7%) | 5 (1.0%) | <0.001 |
| Chronic obstructive pulmonary disease | 30 (3.1%) | 20 (4.1%) | 10 (2.0%) | 0.060 |
| Chronic kidney disease | 127 (13.0%) | 68 (14.0%) | 59 (12.0%) | 0.358 |
| Chronic liver disease | 150 (15.4%) | 76 (15.7%) | 74 (15.1%) | 0.806 |
| Malignancy | 365 (37.4%) | 171 (35.3%) | 194 (39.6%) | 0.162 |
| Shock | 280 (28.7%) | 146 (30.1%) | 134 (27.3%) | 0.342 |
| Type of infection (%) | <0.001 | |||
| Pneumonia | 573 (58.8%) | 339 (69.9%) | 234 (47.8%) | |
| Intra-abdominal infection | 262 (26.9%) | 81 (16.7%) | 181 (36.9%) | |
| Bloodstream infection | 90 (9.2%) | 43 (8.9%) | 47 (9.6%) | |
| Skin and soft tissue infection | 33 (3.4%) | 15 (3.1%) | 18 (3.7%) | |
| Others | 17 (1.7%) | 7 (1.4%) | 10 (2.0%) | |
| Incidence of GNB isolated (%) | 521 (53.4%) | 317 (65.4%) | 204 (41.6%) | <0.001 |
| Mechanical ventilation (%) | 345 (35.4%) | 198 (40.8%) | 147 (30.0%) | <0.001 |
| CRRT (%) | 109 (11.2%) | 64 (13.2%) | 45 (9.2%) | 0.047 |
| Duration of administering antibiotics (days) | 9.0 (7.0–14.0) | 11.0 (8.0–15.0) | 8.0 (6.0–12.0) | <0.001 |
Data are expressed as medians (interquartile range), or number (percentage). ICU: intensive care unit; GNB: Gram-negative bacteria; CRRT: continuous renal replacement therapy.