Table 1.

Cox regression analysis of five years overall survival in 100 COAD patients.

Univariate cox regression analysis	Overall survival
	Hazard Ratio	95% CI	P-value
Age (≥55years vs <55 years)	1.004	0.638-1.581	0.985
Gender (Male vs Female)	1.137	0.723-1.786	0.578
Smoke (Yes vs No)	1.257	0.803-1.968	0.317
Drink (Yes vs No)	0.910	0.579-1.430	0.683
CEA (≥ 5 ng/ml vs < 5 ng/ml)	7.208	3.833-13.555	< 0.001
Tumor size (≥ 5 cm vs < 5 cm)	0.826	0.529-1.289	0.400
Tumor location (right vs left)	0.872	0.557-1.365	0.549
TNM stage (III + IV vs I + II)	4.558	2.638-7.876	< 0.001
Family history (Yes vs No)	1.554	0.855-2.824	0.148
Lymph node metastasis (Positive vs Negative)	8.150	4.035-16.462	< 0.001
CUL7 expression (High vs Low)	9.020	4.347-18.716	< 0.001
Multivariate cox regression analysis	Overall survival
	Hazard Ratio	95% CI	P-value
CEA (≥ 5 ng/ml vs < 5 ng/ml)	1.150	0.320-4.126	0.831
TNM stage (III + IV vs I + II)	2.649	1.330-5.277	0.006
Lymph node metastasis (Positive vs Negative)	1.333	0.329-5.403	0.687
CUL7 expression (High vs Low)	5.302	1.946-14.450	0.001