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. 2022 Oct 11;13:966167. doi: 10.3389/fimmu.2022.966167

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Copyright © 2022 Wang, Peng, Ning, He, Yang, Mao and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The validation of mitophagy-related HCC subtypes using mitophagy signature obtained from cell experiment. (A) A heatmap showing association between subtypes and clinical characteristics. (B) The Kaplan–Meier plot showing distinct prognosis between two subtypes. (C–E) Box plots showing the differences of infiltrating immunocyte abundance (C), immune reaction activity (D), and expression of immune-checkpoint genes (E) between two subtypes. (F) Violin plots comparing the Tumor Immune dysfunction and Exclusion (TIDE) score of each subtype. The asterisks represent the p value (*p < 0.05; **p < 0.01; ***p < 0.001). ns, not significant.