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. 2022 Oct 11;13:966167. doi: 10.3389/fimmu.2022.966167

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Copyright © 2022 Wang, Peng, Ning, He, Yang, Mao and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of two mitophagy-related HCC subtypes with different prognosis. (A–C) Consensus matrix of HCC samples co-occurrence proportion for k = 2 (A), relative change in area under the CDF curve for k from 2 to 7 (B), consensus clustering CDF for k from 2 to 7 (C). (D) Principal component analysis of HCC samples grouped by subtype. (E) A heatmap showing the association of mitophagy-related subtypes with clinical characteristics and expression of DEMs. (F) The Kaplan–Meier plot showing the overall survival differences between the two subtypes. The asterisks represent the p value (*p < 0.05; **p < 0.01; ***p < 0.001). DEMs, Differentially expressed mitophagy-related genes. CDF, Cumulative distribution function.