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. 2022 Oct 11;15:1002842. doi: 10.3389/fnmol.2022.1002842

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Copyright © 2022 Schmidt, Sondermann, Gomez-Varela, Çubuk, Millet, Lewis, Wood and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram for transcriptome and proteome analysis in Na_V1.8-expressing (Na_V1.8⁺) DRG neurons (mainly nociceptors). The diagram shows the key steps of the workflow. First, RNA and protein samples from DRG were collected from both DTA mutant (Na_V1.8Cre^+/−; ROSA26-eGFP-DTA^+/−) mice, in which Na_V1.8⁺ nociceptors have been ablated, and littermate control (Ctrl) mice (Nav1.8Cre^+/+; ROSA26-eGFP-DTA^+/−). Isolated RNA and proteins were identified with Affymetrix microarray and Data Independent Acquisition-Mass Spectrometry (DIA-MS), respectively. Generated datasets were analyzed using Transcriptome Analysis Console (TAC) software for transcriptome profiling, and Spectronaut™ Software (Biognosys AG) for proteome profiling.