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. 2022 Oct 11;13:998574. doi: 10.3389/fphar.2022.998574

FIGURE 2.

FIGURE 2

NF-κB/NLRP3 signaling pathway is involved in the regulation of pyroptosis. (1) NF-κB binds with IκB in inactive form, dissociates the active form of P50/P65 heterodimer upon stimulation. (2) lncRNA XIST/miR-15b-5p/TLR4/NF-κB signaling pathway, AMPK/SIRT1/NF-κB signaling pathway, AMPK/mTOR/NF-κB signaling pathway, DSUP-4/MAPK/NF-κB signaling pathway, ROS/MAPK signaling pathway and FOXM1/SIRT4/NF-κB signaling pathway, they all can regulate the activation of NF-κB. (3) Tisp40 and lncRNA-Gm4419 can promote the activation of NF-κB p65/p50, and XIAP can inhibit the activation of NF-κB. (4) P50 can act with NLRP3 inflammasome and lead to increased expression of pro-inflammatory cytokines and GSDMD-N. (5) NF-κB can promote the transcription of inflammasome genes. (6) Knockdown of SGLT1 partially reduced pyroptosis, ROS generation and NF-κB activation.