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. 2022 Oct 11;13:998574. doi: 10.3389/fphar.2022.998574

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Copyright © 2022 Wan, Liu, Pan, Zhou and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTEN/PI3K/Akt signaling pathway is involved in the regulation of pyroptosis. (1) PPAR can regulate the transcription of PTEN, and METTL3 can also modify PTEN. (2) Upregulation of PTEN can reduce the phosphorylation of PI3K and Akt. SIRT1 can interact with Akt directly, consequently promoting the activity of Akt and inhibiting the production of ROS via Akt/PDH axis. (3) DDX3X can be phosphorylated by Akt, and Akt can increase the phosphorylation of NLRP3. (4) PI3K/Akt/mTOR/NF-κB signaling pathway can also regulate pyroptosis mediated by NLRP3 inflammasome. (5) PTEN directly interacts with NLRP3 and enables NLRP3 inflammasome assembly and activation.