Table 5.

Univariate and Multivariate Cox regression analysis of metastasis-free survival.

	Univariate Analysis			Multivariate Analysis
Variables	HR	95% CI	p-value	HR	95% CI	p-value
Disease-free Survival
Age (years)	0.99	0.97–1.03	0.954
Sex (Male)	0.94	0.54–1.62	0.818
Open Surgical method	1.58	0.94–2.65	0.085
Tumor size (cm)	1.06	0.99–1.13	0.099
Multifocality	1.76	0.75–4.10	0.192
High grade	8.32	1.15–60.15	0.036	2.10	0.26–17.09	0.489
T stage ≥ T2	6.16	3.02–12.55	<0.001	3.41	1.49–7.81	0.004
Concomitant CIS	1.55	0.914–2.63	0.104
Lymphovascular invasion	6.27	3.72–10.56	<0.001	4.21	2.42–7.32	<0.001
eGFR < 60 (mL/min/1.73 m2)	2.35	1.39–3.97	0.001	1.61	0.94–2.77	0.086
Urine B2-MG (> 0.3 ug/mL)	2.18	1.29–3.70	0.004	1.78	1.03–3.07	0.039

CI, confidence interval; CIS, carcinoma in situ; eGFR, estimated glomerular filtration rate.