Table 3.
Significant peaks that are differentially methylated between T2D and controls.
| Chromosome | Start | End | Peak number | Nearest gene | Distance from TSS | Methylation Status |
|---|---|---|---|---|---|---|
| chr22 | 51064477 | 51064877 | Peak117 | ARSA | 1923 | Decreased |
| chr8 | 22412013 | 22412413 | Peak135 | SORBS3 | 3005 | Decreased |
| chr11 | 67810920 | 67811320 | Peak137 | TCIRG1 | 4637 | Decreased |
| chr1 | 11919744 | 11920144 | Peak16 | NPPB | -956 | Increased |
| chr19 | 38016396 | 38016796 | Peak166 | ZNF793 | 2289 | Increased |
| chr1 | 27189779 | 27190179 | Peak176 | SFN | 346 | Decreased |
| chr4 | 190943560 | 190943960 | Peak18 | FRG2 | 4652 | Decreased |
| chr19 | 3767151 | 3767551 | Peak184 | MRPL54 | 4689 | Decreased |
| chr19 | 3767151 | 3767551 | Peak184 | RAX2 | 4882 | Decreased |
| chr19 | 4557053 | 4557766 | Peak185 | SEMA6B | 2410 | Decreased |
| chr16 | 68269125 | 68269525 | Peak190 | ESRP2 | 1162 | Decreased |
| chr20 | 61923486 | 61923886 | Peak205 | COL20A1 | -852 | Decreased |
| chr11 | 823636 | 824345 | Peak21 | EFCAB4A | -3594 | Decreased |
| chr19 | 35843080 | 35843480 | Peak271 | FFAR1 | 835 | Decreased |
| chr11 | 56057882 | 56058282 | Peak272 | OR8H1 | 484 | Decreased |
| chr14 | 21899880 | 21900280 | Peak275 | CHD8 | -213 | Decreased |
| chr11 | 840258 | 840658 | Peak289 | POLR2L | 2087 | Decreased |
| chr11 | 840258 | 840658 | Peak289 | TSPAN4 | -3988 | Decreased |
| chr12 | 108083057 | 108083457 | Peak310 | PWP1 | 3748 | Increased |
| chr12 | 51478875 | 51479275 | Peak320 | CSRNP2 | -1742 | Increased |
| chr22 | 30727674 | 30728074 | Peak338 | TBC1D10A | -4984 | Increased |
| chr11 | 67191345 | 67191745 | Peak34 | RPS6KB2 | -4427 | Decreased |
| chr6 | 24723903 | 24724303 | Peak380 | C6ORF62 | -3039 | Decreased |
| chr11 | 46726740 | 46727140 | Peak381 | ARHGAP1 | -4791 | Decreased |
| chr11 | 46726740 | 46727140 | Peak381 | ZNF408 | 4572 | Decreased |
| chr19 | 1065608 | 1066008 | Peak404 | HMHA1 | -114 | Decreased |
| chr17 | 79782003 | 79782403 | Peak42 | FAM195B | 2335 | Decreased |
| chr13 | 24882421 | 24882821 | Peak428 | C1QTNF9 | 1317 | Decreased |
| chr16 | 58030446 | 58031214 | Peak432 | USB1 | -4447 | Decreased |
| chr16 | 58030446 | 58031214 | Peak432 | ZNF319 | 2932 | Decreased |
| chr6 | 30587385 | 30587785 | Peak435 | MRPS18B | 2099 | Increased |
| chr6 | 30587385 | 30587785 | Peak435 | PPP1R10 | -2564 | Increased |
| chr19 | 35757516 | 35757916 | Peak44 | USF2 | -2252 | Decreased |
| chr2 | 18765729 | 18766129 | Peak458 | NT5C1B | 4883 | Decreased |
| chr9 | 139835090 | 139835490 | Peak51 | C8G | -4423 | Decreased |
| chr9 | 139835090 | 139835490 | Peak51 | FBXW5 | 3812 | Decreased |
| chr5 | 140167607 | 140168007 | Peak64 | PCDHA1 | 1931 | Decreased |
| chr20 | 39990179 | 39990942 | Peak75 | EMILIN3 | 4906 | Decreased |
| chr2 | 241512174 | 241512574 | Peak76 | RNPEPL1 | 4270 | Decreased |
| chr19 | 11642058 | 11642458 | Peak77 | ECSIT | -2269 | Decreased |
| chr13 | 21349929 | 21350329 | Peak81 | N6AMT2 | -2041 | Increased |
| chr17 | 48613911 | 48614311 | Peak87 | EPN3 | 4207 | Decreased |
All the significant peaks that were annotated using GREAT -5000 to 5000 bp of the TSS. Chromosome indicates the chromosome number of the peak, start indicates the start of peak, end indicates the end of peak, peak number is the unique number of a peak, nearest gene indicates the closest gene to the center of the peak, Distance from TSS indicates the distance of the peak from the TSS of the gene. The methylation status is indicated as increased or decreased.