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. 2022 Oct 21;38:65–75. doi: 10.1016/j.jot.2022.09.014

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

SAR131675 effectively inhibits the formation of lymphatic vessels in the injured area after RC injury (A) Representative immunofluorescence images of lymphatic vessels (LYVE-1 and VEGFR-3 co-staining) at the control and SAR131675 groups postoperatively 2 and 4 weeks. The area selected by the rectangle dashed line is the local magnified area. The dashed line denotes repaired insertion of the examples. The white arrow indicates proliferating lymphatic vessels. SB, subchondral bone; ST, supraspinatus tendon; Scale bar = 400 μm. (B) Quantitative analysis of lymphatic vessels positive staining areas at the healing area. n = 6 for each group. ∗P < 0.05.