Table. Characteristics of Study Cohorts Included in the Meta-analysis of Exome Sequencing (ES) and Chromosomal Microarray (CMA) for Cerebral Palsy (CP).
| Study and cohort | Analysis using trios or mixed trios/nontrios | Testing modality | Focus on CP or specific CP motor subtype | CP diagnosis based on standard criteria | CP risk factor classification |
|---|---|---|---|---|---|
| ES for CP | |||||
| McMichael et al,11 2015 | Trios | ES | CP | Yes | Mixture of cryptogenic and noncryptogenic |
| Takezawa et al,23 2018 | Trios | ES, CMA | CP | Not specified | Cryptogenic |
| Jin et al,21 2020 | Trios | ES | CP | Yes | Cryptogenic |
| Jin et al,21 2020 | Trios | ES | CP | Yes | Noncryptogenic |
| Zech et al,25 2020 | Trios and nontrios | ES, CNV analysis | Dystonic CP | Not specified | Mixture of cryptogenic and noncryptogenic |
| Rosello et al,27 2021 | Trios | ES, CMA | CP | Yes | Cryptogenic |
| Moreno-De-Luca et al,18 2021 (clinical lab cohort) | Trios and nontrios | ES, CNV analysis | CP | Not specified | Cryptogenic |
| Moreno-De-Luca et al,18 2021 (health care–based cohort) | Trios and nontrios | ES, CNV analysis | CP | Not specified | Mixture of cryptogenic and noncryptogenic |
| May et al,20 2021 (no risk factor cohort) | Trios and nontrios | ES | CP | Not specified | Cryptogenic |
| May et al,20 2021 (risk factor cohort) | Trios and nontrios | ES | CP | Not specified | Non-cryptogenic |
| Yechieli et al,22 2021 | Trios | ES, CMA | CP | Yes | Cryptogenic |
| Nejabat et al,24 2021 | Trios and nontrios | ES | CP | Yes | Cryptogenic |
| Mei et al,26 2022 | Trios and nontrios | ES, CNV analysis | CP | Yes | Mixture of cryptogenic and noncryptogenic |
| Chopra et al,19 2022 (cryptogenic CP cohort) | Trios and nontrios | ES | CP | Yes | Cryptogenic |
| Chopra et al,19 2022 (non-cryptogenic CP cohort) | Trios and nontrios | ES | CP | Yes | Noncryptogenic |
| CMA for CP | |||||
| Oskoui et al,10 2015 | Trios | CMA | CP | Not specified | Mixture of cryptogenic and noncryptogenic |
| Zarrei et al,28 2018 | Trios | CMA plus ES in n = 23 trios with CNV findings | Hemiplegic CP | Not specified | Mixture of cryptogenic and noncryptogenic |
| Takezawa et al,23 2018 | Trios | ES, CMA | CP | Not specified | Cryptogenic |
| Rosello et al,27 2021 | Trios | ES, CMA | CP | Yes | Cryptogenic |
| Yechieli et al,22 2021 | Trios | ES, CMA | CP | Yes | Cryptogenic |
Abbreviation: CNV, copy number variant.