Table 3.

Comparing Photodynamic therapy to endobiliary radiofrequency ablation

Treatment type	Mechanism	Adverse events	Pros	Cons
Photodynamic therapy	Photosensitizing agent is given intravenously 3-4 d prior to accumulate in tissue; then, a fiberoptic probe is introduced to transmit laser light (approximately 630 nm)-apoptosis, necrosis, and immunomodulatory effect	Phototoxicity, erythema, pruritus, blistering, and diffuse pain	Light waves can refract to the proximal biliary tree, beyond the reach of the guidewire	Expensive; highly specialized equipment needed; decreased quality of life (avoid direct sunlight 4-6 wk after treatment); limited to high specialized centers; lack of FDA approval
Endobiliary radiofrequency ablation	High frequency electromagnetic energy-cell death via thermal energy, coagulative necrosis, and indirect anti-tumor lymphocyte activation	Pancreatitis, cholecystitis, cholangitis hemobilia, abdominal pain	Widely available	Lack of standardization; potentially need > 1 session; can only be performed under fluoroscopy