Table 1.

The characteristics of human RNase A family

RNase	RNase Activity (relative to RNase1)	Net chargea	Expression pattern
			Organsb	Cell typesc
RNase 1	1	+11	Various organs, such as pancreas, lung, stomach, testis and so on	Endothelial cells, acinar cells, oligodendrocyte, enterocytes
RNase 2/EDN	0.65 (Wang et al., 2018b)	+7	Bone marrow	Neutrophils, dendritic cells, monocytes
RNase 3/ECP	4.8 × 10−2(Wang et al., 2018b)	+13	Bone marrow	Neutrophils
RNase 4	∼1(Wang et al., 2018b)	+16	Various organs, such as liver, pancreas, intestine, ovary and so on	Fibroblasts, microglia, macrophages, keratinocytes.
RNase 5/ANG	1 × 10−5(Sheng and Xu, 2016)	+11	Various organs, such as liver, pancreas, intestine, stomach and so on	Microglia, macrophages, hepatocytes, fibroblasts,
RNase 6/RNase k6	2.5 × 10−2 (Rosenberg and Dyer, 1996)	+8	Various organs, such as lymph node, spleen, gall bladder, urinary bladder and so on	Macrophages, dendritic cells, B cells, plasmacytoid dendritic cells,
RNase 7	0.14 (Zhang et al., 2003)	+16	Esophagus, skin, gall bladder	No data
RNase 8	0.08 (Zhang et al., 2003)	+4	Placenta, lung, spleen and testis	No data
RNase 9	Inactive	–	Testes, epididymis	No data
RNase 10	Inactive	–	Epididymis (Krutskikh et al., 2012)	Germ cells
RNase 11	Inactive	–	Testes	No data
RNase 12	Inactive	–	No data	Neutrophils, basophils, eosinophils
RNase 13	Inactive	–	Testes	No data

^atheoretically calculated.

^bdata from NCBI gene expression (www.ncbi.nlm.nih.gov/gene/).

^cdata from single cell RNA sequencing database (PanglaoDB).