Table 1.
Baseline characteristics of patients in septic shock
| G-286A∗rs3087456 |
G-712A∗rs12596540 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AA (n = 92) | AG (n = 84) | GG (n = 27) | All (n = 203) | P Value ∗ | AA (n = 113) | AG (n = 76) | GG (n = 14) | All (n = 203) | P Value ∗ | |
| Age, years | 62 (18-91) | 60 (19-94) | 63 (30-88) | 61 (18-94) | 0.25 | 62 (18-91) | 59 (19-94) | 58 (33-88) | 61 (18-94) | 0.73 |
| Gender, % male | 68.5 | 59.5 | 70.4 | 65 | 0.38 | 66.4 | 63.2 | 64.3 | 65 | 0.90 |
| SAPS II | 49 (22-120) | 49 (15-96) | 45 (19-93) | 49 (15-120) | 0.44 | 48 (22-120) | 50 (15-96) | 44 (19-65) | 49 (15-120) | 0.58 |
| SOFA | 7 (2-15) | 7 (2-16) | 7 (1-16) | 7 (1-16) | 0.87 | 7 (2-15) | 7 (2-16) | 7 (1-11) | 7 (1-16) | 0.91 |
| Surgical, % | 22.8 | 25 | 22.2 | 23.6 | 0.93 | 21.2 | 26.3 | 28.6 | 23.6 | 0.65 |
| Sepsis origin, % | ||||||||||
| Lung | 54.3 | 50 | 59.3 | 53.7 | 0.67 | 56.7 | 47.4 | 64.3 | 53.7 | 0.36 |
| Abdomen | 20.7 | 22.6 | 14.8 | 20.7 | 0.68 | 20.4 | 21.1 | 21.4 | 20.7 | 0.99 |
| Urinary | 4.3 | 4.8 | 3.7 | 4.4 | 0.97 | 3.5 | 5.3 | 7.1 | 4.4 | 0.75 |
| Laboratory variables | ||||||||||
| Leukocyte count, x 103/mm3 | 11.4 (0.1-55) | 12.4 (0.1-92.5) | 9.1 (0.4-32.7) | 11.4 (0.1-92.5) | 0.76 | 10.7 (0.1-55) | 12.3 (0.1-92.5) | 15.8 (1.8-32.7) | 11.4 (0.1-92.5) | 0.42 |
| Neutrophil count, x 103/mm3 | 10.1 (0.1-46.2) | 10.4 (0.1-74.9) | 8.4 (0.5-29.3) | 9.1 (0.1-74.9) | 0.56 | 9.3 (0.1-46.2) | 10.4 (0.1-74.9) | 9.7 (1-28.4) | 9.1 (0.1-74.9) | 0.84 |
| Lymphocyte count, x 103/mm3 | 0.7 (0.1-11.9) | 0.6 (0.1-5.8) | 0.9 (0.2-2.5) | 0.7 (0.1-11.9) | 0.17 | 0.6 (0.1-11.9) | 0.7 (0.1-3.7) | 1.7 (0.2-2.5) | 0.7 (0.1-11.9) | 0.005 |
| Monocyte count, x 103/mm3 | 0.5 (0.1-2.7) | 0.6 (0.1-4.6) | 0.5 (0.1-7.9) | 0.6 (0.1-7.9) | 0.87 | 0.5 (0.1-2.9) | 0.6 (0.1-4.6) | 0.9 (0.1-7.9) | 0.6 (0.1-7.9) | 0.24 |
SAPS II: Simplified Acute Physiology Score II; SOFA = Sequential Organ Failure Assessment. Data are median (interquartile range) for continuous variable. ∗p values were calculated with the use of chi-square test and Kruskal-Wallis test.