Fig. 1.

Liproxstatin-1 reduces hydroperoxide generation in denervated muscle. (A) Lipid Hydroperoxides and mono-oxygenated oxylipins react with amplex red. (B) Hydroperoxide generation in fiber bundles from sham and denervated muscle with liproxstatin-1 treatment in vitro. (C) Hydroperoxide generation in fiber bundles from mice treated daily with either Veh or Liprox. (D) 4-HNE content in gastrocnemius muscle. (E) Representative 4-HNE image. An n = 5–6 per group was used. DN, denervated; Liprox, Liproxstatin-1. Asterisk denotes post hoc differences at an alpha set at P < 0.05.