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Tripeptides in strep tag bind to the cleft between the short and long loops. (A) Cartoon representation of the X-ray structure of the hLang CRD (PDB entry 3P7H).18 A C-terminal strep tag peptide binds to the cleft between the short and long loops (left). The interactions of the peptide with the short and long loops are magnified (right). (B) Structure presentation of tryptophan and the similar structure of the thiazolopyrimidine inhibitor.
