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. Author manuscript; available in PMC: 2023 Jul 6.
Published in final edited form as: J Am Chem Soc. 2022 Jun 23;144(26):11620–11625. doi: 10.1021/jacs.2c01929

Figure 3.

Figure 3.

The F1 binding site was mapped to QSOX1 5’ UTR and F1 was subsequently converted to an RNA degrader. (A) RNA-seq tracks showing regions of the QSOX1 transcript enriched by F1 in cells. (B) The RNA sequence and structure nearby the mapped F1 cross-linking site. (C) Structures of F1-RIBOTAC that recruits RNase L, and F1-CTRL that is >20-fold less active in recruiting RNase L.