Fig. 6.

Volcano plots representing relative abundance of the proteins detected in the SC com-paring NPs of different matrices. A) PLGA vs MIX NPs. B) PLGA vs Chol NPs. C) MIX vs Chol NPs. The dotted line represents the limit of statistical significance; the blue square rep-resents a secondary selection for those proteins that are present at least 2-fold higher in one sample compared to its counterpart. The complete statistical analysis is reported in Fig. S5. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)