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Enriched genes and pathways in Trem2hi macrophages present in cases of atherosclerosis and obesity. Top: single-cell RNA sequencing data from Kim et al.[3] are re-visualized using UMAP clustering. Bottom: The top 65 LAM genes from Jaitin et al.[4▪▪] are highly upregulated in PLAMs (Cluster 7). FC, fold change; LAM, lipid-associated macrophages; PLAM, plaque LAM; PPAR, peroxisome proliferator-activated receptor; UMAP, Uniform manifold approximation and projection.
