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. 2022 Sep 30;26(10):2937–2946. doi: 10.1021/acs.oprd.2c00244

Table 4. Catalyst Optimization for the Direct Guanylation of 24.

graphic file with name op2c00244_0012.jpg

entrya catalyst equiv catalyst conversion (%)
1 Sc(OTf)3 0.1 38
2 Bi(OTf)3 0.1 34
3 Y(OTf)3 0.1 25
4 HCl 1.0 8
5 HNO3 1.0 40
6 AcOH 1.0 11
a

Aniline 28 (0.08 mmol), 1.2 equiv of NH2CN, 1.0 M, 72 h, MeCN/iPrOH 1:1 v/v.