Table 1: Study Drug Schedules and Dose Levels and for Cilengitide and Paclitaxel.

Study drug dosing, route of administration, schedule, and retreatment interval.

Agent	Dose	Route	Schedule	Retreatment
Cilengitide	As assigned by Randomization Center	IV over 1 hour	Levels −4, −3, −2, −1, 1*: Days 1, 8 and 15	Every 21 days +/− 3 days
			Level 2: Days 1, 2, 8, 9, 15, 16
Paclitaxel	As assigned by Randomization Center	IV over 1 hour	Days 1, 8 and 15	Every 21 days +/− 3 days

Dose Level	Cilengitide (mg)		Paclitaxel (mg/m2)
	Dose	Frequency
−4	1500	Once weekly	60
−3	2000	Once weekly	60
−2	2000	Once weekly	70
−1	2000	Once weekly	80
1*	2000	Once weekly	90
2	2000	Twice weekly	90

^*Starting Dose Level