Fig. 7.

CBS mediated cysteine persulfidation may contribute to protection against oxidative inactivation of STAT3. (A-B and D.) Metabolome analyses of steady-state GSH, cysteine and cystine levels, respectively. (C). Protein cysteine persulfidation levels in T3M4 control, shCBS and primary tumor (BxPC3) cells. Metabolites were measured by LC-MS/MS. *P < 0.05, **P < 0.01 show significant differences in shCBS and BxPC3 compared to control T3M4 cells. The data are means ± SEM of 3 independent experiments.