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Schematic representation of this study. B3GALT4 overexpression promotes CXCL9 and CXCL10 expression and secretion via the inhibition of c-Met signaling in the lipid raft, accompanied by the downstream Akt/mTOR/IRF-1 signaling pathway. The secreted chemokines recruit CD8+ T lymphocytes to the tumor microenvironment. In particular, lipid raft inhibitor combined with anti-GD2 mAb significantly suppressed tumor growth in the 9464D-derived tumor xenografts in vivo
