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. 2022 Oct 25;20:165. doi: 10.1186/s12964-022-00966-5

Fig. 1.

Fig. 1

Change in bone resorption and BMD with metformin in postmenopausal women with T2DM. A The β-CTX and TRACP-5b levels in the serum of postmenopausal women taking or not taking metformin for T2DM. B BMD and BMD T-score at LS1; C BMD and BMD T-score at TH. D BMD and BMD T-score at FN. PM, Postmenopausal women (n = 8); PM + MET, metformin-treated postmenopausal women(n = 8); LS1, Lumbar Spine; TH, Total Hip; FN, Femoral Neck. Data are presented as means ± SD of 8 independent experiments (*p < 0.05; **p < 0.01; ***p < 0.001)