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. 2022 Oct 21;42(10):BSR20220314. doi: 10.1042/BSR20220314

Figure 3. Sulfo-ASMO pathway with a representative gene cluster.

Figure 3

In the first step of sulfo-ASMO pathway, oxygenolytic C-S cleavage of SQ catalyzed by the flavin-dependent SQ monooxygenase SquD produces sulfite and 6-dehydroglucose. Many of the sulfo-ASMO gene clusters also encode a SsuE homolog that catalyzes the NAD(P)H-dependent regeneration of the reduced flavin cofactor for SquD. For those that lack SsuE, other flavin reductases may be involved (e.g. in N. aromaticivorans). In the second step, 6-dehydroglucose is reduced to glucose by the NAD(P)H-dependent glucose-6-dehydrogenase SquF, allowing the complete utilization of SQ carbons.