Table 1.
Baseline Demographic Characteristics for ISAR Patients with Severe Asthma and High Oral Corticosteroid Exposure Who Were and Were Not Initiated on Biologic (Bx) Therapy
| BX Not Initiated | BX Initiated | P-value | B‐H Critical P value Threshold for Significance in Multiple Testing | |
|---|---|---|---|---|
| Age, yrs | n = 416 | n = 996 | ||
| Mean (SD) | 53.2 (14.5) | 51.7 (13.9) | 0.075 | |
| 18–34, n (%) | 50 (12.0) | 131 (13.2) | 0.010 | 0.028 |
| 35–54, n (%) | 153 (36.8) | 418 (42.0) | ||
| 55–79, n (%) | 203 (48.8) | 440 (44.2) | ||
| 80+, n (%) | 10 (2.4) | 7 (0.7) | ||
| Gender | n = 416 | n = 996 | ||
| Female, n (%) | 277 (66.6) | 609 (61.1) | 0.050 | 0.040 |
| Race/Ethnicity | n = 375 | n = 887 | ||
| Caucasian, n (%) | 244 (65.1) | 689 (77.7) | <0.001 | 0.007 |
| Asian, n (%) | 65 (17.3) | 62 (7.0) | ||
| African, n (%) | 10 (2.7) | 36 (4.1) | ||
| Mixed, n (%) | 1 (0.3) | 17 (1.9) | ||
| Other†, n (%) | 55 (14.7) | 83 (9.4) | ||
| BMI Category, Kg/m2 | n = 410 | n = 960 | ||
| Mean (SD) | 29.7 (7.7) | 29.3 (6.8) | 0.280 | 0.066 |
| Underweight (BMI <18.5), n (%) | 11 (2.7) | 13 (1.4) | 0.310 | 0.071 |
| Normal (BMI 18.5 to <25), n (%) | 106 (25.9) | 264 (27.5) | ||
| Overweight (BMI 25 to <30), n (%) | 126 (30.7) | 309 (32.2) | ||
| Obese (BMI ≥30), n (%) | 167 (40.7) | 374 (39.0) | ||
| Tobacco smoking status † | n = 410 | n = 936 | ||
| Current smoker, n (%) | 23 (5.6) | 23 (2.5) | 0.010 | 0.029 |
| Ex-smoker, n (%) | 106 (25.9) | 267 (28.5) | ||
| Non-smoker, n (%) | 281 (68.5) | 646 (69.0) | ||
| Tobacco smoking pack-years† | n = 117 | n = 249 | ||
| Mean (SD) | 15.25 (16.31) | 18.97 (17.62) | 0.050 | 0.041 |
| <6, n (%) | 41 (35.0) | 56 (22.5) | 0.011 | 0.033 |
| ≥6, n (%) | 76 (65.0) | 193 (77.5) | ||
| ≤10, n (%) | 67 (57.3) | 105 (42.2) | 0.007 | 0.021 |
| >10, n (%) | 50 (42.7) | 144 (57.8) |
Notes: †does not include hookah smoking. Test statistics: Pearson Chi Square test for categorical variables with > 2 categories, McNemar’s test for categorical variables with 2 categories and T-test for continuous variables.
Abbreviations: B-H, Benjamini-Hochberg Procedure; BMI, body mass index; ISAR, International Severe Asthma Registry; SD, standard deviation.