Figure 3.

Average number of iSNVs observed in SARS-CoV-2-positive samples

Number of iSNVs seen in each sample of the SARS-CoV-2 lineages sub-divided based on (A) vaccination status (vaccinated and unvaccinated) and (B) mRNA vaccine type (mRNA-1273 [Moderna] and BNT162b2 [Pfizer]). All mutations were included except for those located in intragenic regions and in the upper and lower untranslated regions of the genome. Each bar represents the mean iSNVs value ±SD. Significance is indicated as follows: ∗ for <0.033, ∗∗ for <0.0021, ∗∗∗ for <0.0002, and ∗∗∗∗ for <0.0001. A detailed linear model analysis that incorporates the interaction between the virus lineage and vaccine type is demonstrated in Figure S1 and File S1.