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. 2022 Oct 23;8(1):11–19. doi: 10.1016/j.synbio.2022.10.002

Fig. 3.

Fig. 3

Heparan sulfate serves as a receptor for viral attachment. Heparan sulfate interacts with the receptor-binding domain of spike glycoprotein, adjacent specific entry receptor, shifting the spike structure to an open conformation to facilitate ACE2 binding.