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. 2022 Oct 24;401(10378):789–794. doi: 10.1016/S0140-6736(22)01840-2

Figure.

Figure

Transmission of zoonotic diseases

Stages involved in a pandemic crisis, from the initial circulation of pathogens within wild fauna and the natural environment, to the global dissemination after large-scale human-to-human transmission. Anthropological factors lead to changes in pathogen circulation and to increased contacts with new animal species, including domestic ones, which can induce spillover, with possible transmission to humans. The COVID-19 pandemic highlights the risk of reverse zoonoses, due to intensive circulation of SARS-CoV-2 in humans, transmission to new animal species, and circulation within some that have proven to be highly susceptible (hamsters, minks, and wild-tailed deer), with possible transmission of a mutated virus to humans. New variants can also emerge from circulation within humans.