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. 2022 Oct 13;20(10):e3001805. doi: 10.1371/journal.pbio.3001805

Fig 1. A surfaceome-focused CRISPRa screen identified cellular receptors binding with SARS-CoV-2 spike protein.

Fig 1

(A) Schematic of a focused CRISPRa screen for surface proteins interacting with SARS-CoV-2 spike S1-Fc fusion protein. (B) Volcano plots showing sgRNAs enriched or depleted in cells binding with SARS-CoV-2 spike S1-Fc or human IgG isotype control. Results from 2 biologically independent replicates are shown. For underlying data, see S1 Data. ACE2, angiotensin-converting enzyme 2; CRISPRa, CRISPR activation; dCas9, “dead” Cas9; IgG, immunoglobulin G; LRRC15, leucin-rich repeat-containing 15; SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2; sgRNA, single guide RNA.