. Author manuscript; available in PMC: 2022 Oct 25.

Published in final edited form as: Mod Pathol. 2021 Apr 6;34(8):1495–1506. doi: 10.1038/s41379-021-00796-9

Table 3.

Clinicopathologic features of upgraded cases

	Age	Radiologic target	Concordance	CNB			Excision				Surgery	Radiation/Hormonal therapy
				Diagnosis	LCIS		Diagnosis	(micro)invasive carcinoma
				Diagnosis	ER	HER2	Diagnosis	ER	PR	HER2
1	79	Calcifications	Yes	FLCIS with necrosis	pos	neg	ILC multiple foci (largest 4 mm); LCIS-PF, LN 0/1	pos	pos	Neg	lumpectomy	yes/no
2	75	Calcifications	Yes	PLCIS with necrosis and apocrine features + FLCIS with apocrine features	pos	neg	PLCIS and FLCIS with microinvasion	na^*	na^*	na^*	lumpectomy	no/no
3	68	Calcifications	Yes	PLCIS with necrosis and apocrine features + FLCIS with apocrine features	pos	pos	ILC (5 mm); FLCIS, LN 0/3	Pos	Pos	Neg	lumpectomy	yes/yes
4	61	Calcifications	Yes	FLCIS with necrosis	pos	neg	FLCIS with microinvasion, LN 0/4	Pos	neg	Neg	mastectomy	no/yes
5	61	Calcifications	Yes	FLCIS with necrosis	pos	neg	CLCIS with microinvasion, LN 0/1	na^*	na^*	na^*	lumpectomy	yes/no
6	78	Calcifications	Yes	FLCIS with necrosis	pos	neg	PLCIS and FLCIS with microinvasion	pos	Pos	pos	lumpectomy	no/yes

The foci of microinvasion were not present in deeper sections submitted for immunohistochemistry ILC invasive lobular carcinoma