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. 2022 Oct 14;32(10):1193–1200. doi: 10.1089/thy.2022.0217

Table 2.

Evaluation of Calcitonin and Carcinoembryonic Antigen as Markers of Recurrence After Resection in High- and Low-Grade Medullary Thyroid Cancer

Tumor marker value n Low grade (n = 95) High grade (n = 22) p
CEA
 Median CEA 6 months postoperative (ng/mL) (min, max) 71 2.5 (0.6, 33.4) 4.1 (1.0, 59.0) 0.11
 Median CEA 12 months postoperative (ng/mL) (min, max) 85 2.3 (0, 34.0) 4.0 (0.8, 2657) 0.25
 CEA doubling time
  Median time if doubled (months) (min, max) 97 36.8 (21.2, 111.2) 8.8 (3.2, 24.4) <0.001
  <1 Year   0/95 (0%) 11/22 (50.0%)  
  1–2 Years   1/95 (1.1%) 0/22 (0%)  
  2 or more years   11/95 (11.6%) 1/22 (4.5%)  
  Never doubled   67/95 (70.5%) 6/22 (27.2%)  
  Unknown   16/95 (16.8%) 4/22 (18.2%)  
Calcitonin
 Median calcitonin 6 months postoperative (pg/mL) (min, max) 111 1.5 (0, 14,800) 210.0 (0, 8900) 0.21
 Median calcitonin 12 months postoperative (pg/mL) (min, max) 112 0.1 (0, 10,400) 415.0 (3, 36,800) 0.20
 Calcitonin doubling time
  Median time if doubled (months) (min, max) 115 31.6 (15.6, 111.4) 8.7 (2.6, 23.5) <0.001
  <1 Year   0/95 (0%) 16/22 (72.7%)  
  1–2 Year   6/95 (6.3%) 4/22 (18.2%)  
  2 or more years   23/95 (24.2%) 0/22 (0%)  
  Never doubled   65/95 (68.4%) 1/22 (4.5%)  
  Unknown   1/95 (1.1%) 1/22 (4.5%)  

Bold values signify statistical significance.