Table 2.
Tumor marker value | n | Low grade (n = 95) | High grade (n = 22) | p |
---|---|---|---|---|
CEA | ||||
Median CEA 6 months postoperative (ng/mL) (min, max) | 71 | 2.5 (0.6, 33.4) | 4.1 (1.0, 59.0) | 0.11 |
Median CEA 12 months postoperative (ng/mL) (min, max) | 85 | 2.3 (0, 34.0) | 4.0 (0.8, 2657) | 0.25 |
CEA doubling time | ||||
Median time if doubled (months) (min, max) | 97 | 36.8 (21.2, 111.2) | 8.8 (3.2, 24.4) | <0.001 |
<1 Year | 0/95 (0%) | 11/22 (50.0%) | ||
1–2 Years | 1/95 (1.1%) | 0/22 (0%) | ||
2 or more years | 11/95 (11.6%) | 1/22 (4.5%) | ||
Never doubled | 67/95 (70.5%) | 6/22 (27.2%) | ||
Unknown | 16/95 (16.8%) | 4/22 (18.2%) | ||
Calcitonin | ||||
Median calcitonin 6 months postoperative (pg/mL) (min, max) | 111 | 1.5 (0, 14,800) | 210.0 (0, 8900) | 0.21 |
Median calcitonin 12 months postoperative (pg/mL) (min, max) | 112 | 0.1 (0, 10,400) | 415.0 (3, 36,800) | 0.20 |
Calcitonin doubling time | ||||
Median time if doubled (months) (min, max) | 115 | 31.6 (15.6, 111.4) | 8.7 (2.6, 23.5) | <0.001 |
<1 Year | 0/95 (0%) | 16/22 (72.7%) | ||
1–2 Year | 6/95 (6.3%) | 4/22 (18.2%) | ||
2 or more years | 23/95 (24.2%) | 0/22 (0%) | ||
Never doubled | 65/95 (68.4%) | 1/22 (4.5%) | ||
Unknown | 1/95 (1.1%) | 1/22 (4.5%) |
Bold values signify statistical significance.