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. 2022 Oct 13;31(19-20):604–620. doi: 10.1089/scd.2021.0279

FIG. 3.

FIG. 3.

Young tumors and ASCs exhibit a comparable inflammatory profile. (A) Young and aged ASC cytokine profile was assessed using cytokine array analysis. Young ASC cytokine expression is normalized to aged, N = 2 biological replicates. (B) TCGA data of young ER-α+ tumors parallel young ASC cytokine expression. Genes, including CCL5, CD40L, CXCL1, CXCL12, IFN-γ, IL-16, IL-32, and TNF-α, are elevated in both young ER-α+ tumors and young ASCs. Genes, including CCL5, CD40L, GM-CSF, IL-4, IL-16, IL-32a, and SDF-1, show significance (*P < 0.05) between aged and young tumors. Young tumor gene expression is normalized to aged. CCL5, C-C motif chemokine ligand 5; CD40L, CD40 ligand; CXCL1, C-X-C motif chemokine ligand 1; CXCL10, C-X-C motif chemokine ligand 10; CXCL11, C-X-C motif chemokine ligand 11; GMCSF, granulocyte macrophage colony stimulating factor; IFN-γ, interferon gamma; IL, interleukin; MCP-1, monocyte chemoattractant protein 1; PAI-1, plasminogen activator inhibitor 1; TNF-α, tumor necrosis factor alpha.