Table 2.
Comparison of Young Tumors and Young Adipose-Derived Stromal/Stem Cell Cytokine Expression and Their Role in Wound Healing
| ASC-secreted factor | Role in wound healing | Elevated in young tumors | Elevated in young ASCs |
|---|---|---|---|
| MCP-1 | Macrophage chemoattractant Possible macrophage polarization |
No | Yes |
| CXCL12 | Macrophage polarization | Yes | Yes |
| IL-10 | Anti-inflammatory cytokine | No | Yes |
| IL-8 | Neutrophil recruitment | No | Yes |
| TNF | Conflicting-shown to accelerate vascularization but also delays wound healing | Yes | Yes |
| CCL5 | Macrophage recruitment | Yes | Yes |
ASCs, adipose-derived stromal/stem cells.