TABLE 3.
Predictors of histologic abnormalities of the gastric mucosa among patients carrying cagA+ H. pylori strains, by multivariate analysis
| Variable | OR (95% CI) for histologic findinga
|
||||
|---|---|---|---|---|---|
| Mononuclear cell infiltration | Neutrophil infiltration | Atrophy | Metaplasia | H. pylori density | |
| Female sex | NS | 0.2* (0.5–0.9) | NS | NS | 0.08+ (0.01–0.5) |
| Age | NS | NS | 2.1* (1.2–3.5) | NS | NS |
| IL-8 | NS | NS | NS | NS | NS |
| IL-6 | 2.2+ (1.2–4.1) | NS | NS | NS | NS |
| Whole-cell IgG | 2.5+ (1.3–5.0) | NS | NS | NS | NS |
| Whole-cell IgA | NS | NS | NS | NS | NS |
| CagA IgG | NS | 2.8+ (1.5–5.2) | NS | NS | 3.9+ (1.8–8.4) |
| CagA IgA | NS | NS | NS | 0.57* (0.3–0.9) | NS |
| HspA | NS | NS | NS | NS | NS |
| HspB | NS | NS | NS | NS | NS |
a
OR, odds ratio; 95% CI, 95% confidence interval; NS, not significant; ∗, P < 0.05; +, P < 0.005.