Table 2.
Z-scores calculated from somatic, cognitive, anxiety, and locomotor parameters.
| Type | Experimental groups | Z-score ± SEM | Genotype | Surgery | Interaction |
|---|---|---|---|---|---|
| Somatic | Control-Sham | (−0.0070) ± 0.1387 | p = 0.2902 | p = 0.0010 | p = 0.0000 |
| Control-OVX | 3.8905 ± 0.5631 | ||||
| 3xTg-AD-Sham | 0.6443 ± 0.4267 | ||||
| 3xTg-AD-OVX | 3.7049 ± 0.4227 | ||||
| Cognitiv | Control-Sham | (−0.000) ± 0.1197 | p = 0.6754 | p = 0.3038 | p = 0.2349 |
| Control-OVX | 0.1442 ± 0.1645 | ||||
| 3xTg-AD-Sham | 0.0302 ± 0.2340 | ||||
| 3xTg-AD-OVX | 0.2686 ± 0.1861 | ||||
| Anxiety | Control-Sham | 0.0000 ± 0.3964 | p = 0.0002 | p = 0.8743 | p = 0.0000 |
| Control-OVX | (−0.2518) ± 0.4862 | ||||
| 3xTg-AD-Sham | (−2.0022) ± 0.2444 | ||||
| 3xTg-AD-OVX | (−1.6222) ± 0.3366 | ||||
| Locomotor | Control-Sham | 0.000 ± 0.4750 | p = 0.0001 | p = 0.6097 | p = 0.0000 |
| Control-OVX | (−0.4145) ± 0.6432 | ||||
| 3xTg-AD-Sham | (−2.4225) ± 0.4375 | ||||
| 3xTg-AD-OVX | (−2.5365) ± 0.3748 |
Data are expressed as z-score (mean) ± SEM. Statistical data (two-way ANOVA) is presented. Significant differences are marked with red, bold numbers. OVX, ovariectomy; 3xTg-AD, triple transgenic mouse model of Alzheimer’s disorder.