Table 2. Comparison of immune mediators in cervicovaginal lavage samples pre- and post-first sexual intercourse.

Results of univariate mixed-effect models with first sex as fixed effect and participant as random effects. Mean log2 pg/mL difference values above 0 indicate higher concentrations post-first sex. Ratio indicates the multiplicative ratio of post over pre-sex (on a linear scale), so a ratio of 1 indicates no difference, ratios >1 indicate higher post, and ratios <1 indicate higher pre. The ratio is calculated as 2^mean log2 difference. Adjusted p-values are adjusted by Holm-Bonferroni for 19 immune mediators.

Immune mediator	Mean log2 difference	Standard error	Ratio (95% CI)	p-Value	Adjusted p-value
IL-2	0.90	0.25	1.86 (1.32–2.62)	4.7E-4	0.009
IL-1β	1.33	0.43	2.51 (1.4–4.51)	0.002	0.044
CXCL8	1.01	0.33	2.02 (1.29–3.17)	0.003	0.045
IL-1α	0.67	0.24	1.59 (1.15–2.2)	0.006	0.088
CCL3	0.62	0.22	1.53 (1.13–2.07)	0.006	0.091
IL-17A	0.64	0.25	1.56 (1.11–2.18)	0.011	0.154
TNF-α	0.69	0.29	1.61 (1.08–2.39)	0.020	0.236
CXCL10	0.74	0.32	1.67 (1.08–2.57)	0.021	0.236
CXCL9	0.60	0.26	1.51 (1.07–2.14)	0.021	0.236
IL-1RA	0.48	0.22	1.39 (1.03–1.88)	0.032	0.258
IL-6	0.81	0.39	1.75 (1.03–2.98)	0.041	0.284
CCL4	0.42	0.27	1.33 (0.93–1.92)	0.124	0.621
CCL20	0.53	0.36	1.44 (0.88–2.34)	0.146	0.621
CCL5	0.39	0.28	1.31 (0.9–1.92)	0.166	0.621
IL-18	0.44	0.36	1.35 (0.83–2.22)	0.232	0.621
IL-7	0.02	0.18	1.01 (0.79–1.3)	0.921	0.921