TABLE 1.
Composition of different surfactant preparations compared to human natural surfactant
| Component | % Composition (wt/wt)a
|
|||||
|---|---|---|---|---|---|---|
| Alveofact | Curosurf | Survanta | Exosurf | Pumactant | Natural surfactant | |
| Phospholipidsb | 88 | 99 | 84 | 82 | 100 | 81 |
| PC | 72 | 78 | 62 | 82 | 70 | 63 |
| Lyso-PC | <1 | <1 | 1 | 0 | 0 | 0.5 |
| PG | 8 | 3.5 | 2.5 | 0 | 30 | 5 |
| Cholesterol and neutral lipids | 4 | 0 | Not stated | 0 | 0 | 5–10 |
| Free fatty acids | 0.5 | <0.5 | 6 | 0 | 0 | 1.5 |
| Proteins | 1.5 (only SP-B and SP-C) | 1 (only SP-B and SP-C) | 0.5–1 (only SP-B and SP-C) | 0 | 0 | 5–10 (SP-A, SP-B, SP-C, SP-D) |
| Other components | Not statedc | Not statedc | DPPC, neutral lipids are addedc | 11 (cetyl-alcohol), 7 (tyloxapol)c | None | 1 (carbohydrates, antioxidants, anionic peptides, etc.) |
a
Values are modified from references 30 and 37 and from product information. Source: Alveofact, bovine lung lavage; Curosurf, porcine lung homogenate; Survanta, bovine lung homogenate; Exosurf, synthetic; Pumactant, synthetic; natural surfactant, human amniotic fluid. SP, surfactant protein.
b
PC, phosphatidylcholine; PG, phosphatidylglycerol.
c
All preparations contain various amounts of sodium chloride and/or other stabilizing agents (e.g., sodium hydrogen carbonate).