Figure 7.

Re-introducing RGS3 rescued the phenotype induced by UBE2MP1 depletion. (A) Depletion of miR-145-5p significantly increases the expression of RGS3 in HepG2 cells (*P<0.05, **P<0.01). (B) Validation of the re-introduction of RGS3 in HepG2 cells treated with UBE2MP1 depletion (**P<0.01). (C) No significant changes were induced on miR-145-5p and UBE2MP1 transcript expression by re-introducing RGS3. (D, E) The suppressed cell proliferation was significantly recovered along with the escape of the G0/G1 stage arrest by re-introducing RGS3 (*P<0.05, **P<0.01). (F) The increased number of apoptotic cells declined in HepG2 cells with UBE2MP1 depletion when RGS3 was re-introduced (**P<0.01).