Table 2.
Follow-up for cancer incidence and all-cause mortality in the children of the fetal-exposure cohort and childhood-exposure cohort
| Fetal-Exposure Cohort a | United States | Ontario, Canada | Total | ||
| Row % | Row % | ||||
| Total Children, n | 881,205 | 25.4% | 2,592,795 | 74.6% | 3,474,000 |
| Total No. of Person-Years of Follow-up | 9,528,259 | 25.3% | 28,131,322 | 74.7% | 37,659,582 |
| Childhood Leukemia Cases, n (%) b | 534 | 20.3% | 1,860 | 70.6% | 2,394 |
| Cumulative Incidence (95% CI) of Childhood Leukemia at Age 20, n/100,000 children | 94.0 (84.1, 104.9) | 113.9 (107.5, 120.7) | |||
| Childhood Acute Lymphoid Leukemia Cases, n (%) | 390 | 22.0% | 1,386 | 78.0% | 1,776 |
| Cumulative Incidence (95% CI) of Childhood Acute Lymphoid Leukemia at Age 20, n/100,000 children | 64.3 (57.4, 71.9) | 80.3 (75.4, 85.5) | |||
| Childhood Acute Myeloid Leukemia Cases, n (%) | 83 | 14.9% | 474 | 85.1% | 557 |
| Cumulative Incidence (95% CI) of Childhood Acute Myeloid Leukemia at Age 20, n/100,000 children | 15.9 (12.0, 20.9) | 33.6 (29.6, 38.1) | |||
| Other Childhood Cancers, n (%) | 929 | 19.0% | 3,283 | 67.0% | 4,212 |
| Cumulative Incidence (95% CI) of Other Cancers at Age 20, n/100,000 children | 228.8 (207.1, 252.3) | 297.0 (282.7, 311.9) | |||
| Deaths, n (%) | 2,211 | 20.2% | 8,739 | 79.7% | 10,950 |
| Cumulative Incidence (95% CI) of Deaths at Age 20, n/100,000 children | 429.0 (401.3, 458.3) | 509.0 (492.6, 525.8) | |||
| Childhood-Exposure Cohort a | United States | Ontario, Canada | Total | ||
| Row % | Row % | ||||
| Total Children, n | 931,120 | 25.0% | 2,793,512 | 75.0% | 3,724,632 |
| Total No. of Person-Years of Follow-up | 6,092,540 | 16.8% | 30,097,487 | 83.2% | 36,190,027 |
| Childhood Leukemia Cases, n (%) b | 404 | 17.0% | 1,968 | 83.0% | 2,372 |
| Cumulative Incidence (95% CI) of Childhood Leukemia at Age 20, n/100,000 children | 114.2 (91.9, 141.1) | 110.9 (104.8, 117.4) | |||
| Childhood Acute Lymphoid Leukemia Cases, n (%) | 304 | 16.8% | 1,506 | 83.2% | 1,810 |
| Cumulative Incidence (95% CI) of Childhood Acute Lymphoid Leukemia at Age 20, n/100,000 children | 75.9 (64.6, 88.9) | 78.8 (74.2, 83.7) | |||
| Childhood Acute Myeloid Leukemia Cases, n (%) | 59 | 11.3% | 462 | 88.7% | 521 |
| Cumulative Incidence (95% CI) of Childhood Acute Myeloid Leukemia at Age 20, n/100,000 children | 14.7 (9.6, 22.2) | 32.2 (28.3, 36.5) | |||
| Other Childhood Cancers, n (%) | 622 | 15.6% | 3,364 | 84.1% | 3,986 |
| Cumulative Incidence (95% CI) of Other Cancers at Age 20, n/100,000 children | 256.3 (218.5, 299.4) | 282.1 (269.0, 295.8) | |||
| Deaths, n (%) | 793 | 16.1% | 4,122 | 83.9% | 4,915 |
| Cumulative Incidence (95% CI) of Deaths at Age 20, n/100,000 children | 343.5 (280.6, 417.5) | 323.6 (308.9, 338.9) | |||
a
Fetal-Exposure Cohort had 0 months of lag time for cancer fo low-up. Childhood-Exposure Cohort had 6 months of lag time for cancer follow-up.
b
Childhood leukemia cases included acute lymphoid leukemias, acute myeloid leukemias, chronic myeloproliferative disorders and leukemias, myelodysplastic syndrome and other myeloproliferative disorders, and unspecified and other specified leukemias (Supplemental Table 2).