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. 2022 Jul 21;18(11):1177–1183. doi: 10.1038/s41589-022-01065-9

Extended Data Fig. 3. Comparison of the chemical structures of G12Si-1 (this work), adagrasib, ARS1620, and sotorasib.

Extended Data Fig. 3

The electrophile portion of each compound is highlighted in red (serine-targeting) or orange (cysteine-targeting).