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. 2022 Jul 21;18(11):1177–1183. doi: 10.1038/s41589-022-01065-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Measurement of K_i and k_inact for the reactions a) between K-Ras(G12S)•GDP and G12Si-1, b) between K-Ras(G12S)•GDP and G12Si-5. For each kinetic curve, k_obs was determined by fitting the data to a first-order kinetic model. Replicates are plotted as individual data points in the right panel. See Methods section for additional details on data analysis.