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. 2022 Sep 26;18(11):1184–1195. doi: 10.1038/s41589-022-01116-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — Each cyclophilin was titrated against 0.5 nM fluorescein-labeled macrocycle a, A26-Fl; b, B52-Fl; or c, B53-Fl. Trends for selectivity follow those observed in the prolyl-isomerase assay. Cyclophilins in the legend below the dashed line are either prolyl-isomerase inactive or require much higher concentrations to observe prolyl isomerization in vitro. K_d values and error bars reflect mean ± s.e.m. of three technical replicates. Data points and error bars reflect mean ± s.d. of individual assays at one dose.

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