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. 2022 Oct 25;12:17863. doi: 10.1038/s41598-022-21722-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of anti-DENV antibody responses in infected individuals with different immune status and clinical outcome. Graphical summary of plasma samples collected in cohort 2 (A). Plasma samples were collected at day 6 to day 8 after the day after laboratory-confirmed infection. Plasma samples in cohort 2 were analyzed for DENV IgG titer (B, G), percentage of IgG binding to DENV-1-infected cells (DENflow) (C, H), neutralizing antibodies (FRNT90) to DENV-1 (D, I) and ADE activity to DENV-1 expressed as PET (E, J) and AUC (F, K). Each point in the box plot represents an individual plasma sample. Whiskers show max, min, median values and the interquartile range beyond the 25th and 75th percentiles. Mann–Whitney test was used to compare groups. (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).