Table 3.
Risk of cardiovascular disease (CVD) among patients with a diagnosis of cancer, compared with their matched unexposed individuals, by different genetic risk of CVD.
| Characteristics | <3 months of follow-up | 3–6 months of follow-up | >6 months of follow-up | |||
|---|---|---|---|---|---|---|
| No. of CVD (incidence rated) in cancer patients/matched unexposed individuals | Hazard ratio (95% confidence interval) | No. of CVD (incidence rated) in cancer patients/matched unexposed individuals | Hazard ratio (95% confidence interval) | No. of CVD (incidence rated) in cancer patients/matched unexposed individuals | Hazard ratio (95% confidence interval) | |
| By CVD polygenic risk score, by tertilesa | ||||||
| Low | 423 (82.83)/309 (12.52) | 7.71 (5.86–10.14) | 229 (47.00)/294 (12.19) | 3.93 (2.95–5.25) | 2864 (19.07)/10,818 (14.95) | 1.26 (1.19–1.35) |
| Intermediate | 416 (84.52)/405 (16.30) | 5.36 (4.24–6.77) | 238 (50.60)/342 (14.10) | 4.03 (3.01–5.39) | 2944 (20.58)/12,371 (17.09) | 1.17 (1.10–1.24) |
| High | 399 (82.1)/470 (18.86) | 4.26 (3.38–5.38) | 249 (53.65)/482 (19.83) | 2.41 (1.88–3.09) | 3360 (23.69)/14,328 (19.78) | 1.15 (1.08–1.22) |
| pdifferenceb | 0.0012 | 0.012 | 0.039 | |||
| By CVD family historyc | ||||||
| No | 648 (80.10)/490 (12.30) | 6.52 (5.51–7.71) | 326 (42.19)/461 (11.85) | 3.61 (2.96–4.39) | 4329 (18.41)/16,345 (14.06) | 1.30 (1.25–1.36) |
| Yes | 864 (77.45)/926 (16.02) | 4.89 (4.36–5.48) | 532 (49.86)/919 (16.28) | 3.11 (2.74–3.54) | 6903 (20.97)/29,588 (17.45) | 1.17 (1.14–1.21) |
| pdifference | 0.0055 | 0.21 | 0.00013 | |||
aCox model was used to estimate hazard ratios (HRs), stratified by the matching variables (i.e. birth year and sex) and adjusted for birth year, Townsend deprivation index, educational attainment, body mass index, alcohol status, smoking status, physical activity, diet types, history of psychiatric disorders, and history of somatic disease.
bThe differences in hazard ratios for CVD polygenic risk score were assessed between low and high subgroups by Wald test.
cCox model was used to estimate hazard ratios (HRs), stratified by the matching variables (i.e. birth year and sex), and adjusted for birth year, race/ethnicity, Townsend deprivation index, educational attainment, body mass index, alcohol status, smoking status, physical activity, diet types, history of psychiatric disorders, and history of somatic disease.
dNumber of cases per 1000 person-years.