Table 1.
Cohort characteristics for the included participants (modified intention-to-treat [mITT] with Spectralis imaging).
| Sham pooled (N = 64) |
APL-2 monthly (N = 67) |
APL-2 EOM (N = 61) |
P-value for the between group difference* | |
|---|---|---|---|---|
| Age in years | ||||
| Mean (SD) | 78.0 (7.62) | 80.1 (7.44) | 80.3 (7.43) | 0.16 |
| Median [Min, Max] | 78.0 [60.0, 96.0] | 81.0 [63.0, 95.0] | 80.0 [60.0, 97.0] | |
| Sex | ||||
| F | 38 (59.4%) | 44 (65.7%) | 40 (65.6%) | 0.71 |
| M | 26 (40.6%) | 23 (34.3%) | 21 (34.4%) | |
| Laterality | ||||
| L | 31 (48.4%) | 27 (40.3%) | 20 (32.8%) | 0.21 |
| R | 33 (51.6%) | 40 (59.7%) | 41 (67.2%) | |
| Study eye SQRT-transformed area of RPE-atrophy in mm | ||||
| Mean (SD) | 2.78 (0.725) | 2.75 (0.663) | 2.88 (0.772) | 0.60 |
| Median [Min, Max] | 2.65 [1.60, 4.07] | 2.74 [1.59, 4.16] | 3.00 [1.59, 4.12] | |
Retinal pigment epithelium, RPE; SQRT, square-root.
*Between-group differences in continuous variables (age and sqrt. area of atrophy) were evaluated with an ANOVA, and Fisher's exact test was applied for categorical data (sex and laterality).